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????????????????????????????????????'???2020-09-30????????????1095

?????????2??'a???????????????????????????????????????3??????-????????-|??????The Lancet Oncology; IF???33.7???????????oa???????'?????????o????'???1?????????????????????--??o?o?????o????????'??????????????-????????????????????????????a????????????o??????

  

  

  

??????????????????????????????????????1????????????????40%??????????????????-??o????????????????????????????????'????1???o??????????????Helicobacter pylori???H. pylori????????????????o???????'???1?????????????????'?o???????????????????????'?????????????1'???????????????-|??????????????o????1?????????o????????3???????????Genome-wide association study, GWAS?????????????'????o?10?????a?????????????o??????????????o????????????1?????|??????????????????????????????1???????????oo???????????????o?1??????????oo?????????????????????????????????????????????????????o???????????????-?????????o????????3????????|?????oo???????????o????????o?-??????????-????oo???????????o????????3????????????'???10254?????????????????10914???????????1?????????1???o?o????????3???????????????????o?o???-????oo???????????o????????????????????Polygenic Risk Score???PRS??????????????-??o??????????o?????-?????????????????????????????????China Kadoorie Biobank???CKB??????10?????????????????1??????????????o?PRS???????????????????????3?3?????1??3?????????o?????o????'???1????????????????'????????????????1??????????????????????

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???????????????????o?-?????????????????o????????'?????????????1????|?????o????????????????????????????o?????????????????PRS?????????????????????????????????2?o?????-????????????????????????????????????????????1?o??????????????????????o????'???1??????????????1??????????PRS?o????o?????????????????oo???'????????????????????????????????o???2???????o????'???1??????H. pylori??1?2????????o??o???2?????????-??????????????????????1????

???????????????????????1?????????????????????a??????-|??o???-????1?????????2??'a??????????????????????????????-??o??1???????????3??????????????o?????????Joint Last Author???

????'???2020?1'9???

?????????The Lancet Oncology

????????Genetic risk, incident gastric cancer, and healthy lifestyle: a meta-analysis of genome-wide association studies and prospective cohort study

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