???

??????-|????????-?oTNS3???SEPT7???????????????o?????????????????????3

????????????????????????????????????'???2021-05-26????????????57

????????????o????????-|????????????-|??????????????-|?3????3?????????????Nature???????-????NPJ Precision Oncology (IF=7.717?????-????JCR????-|1??o??????)?????o?????????o???????-|???????????????????????????????1??o?o???o?????????????o?????????????????????????????????????-|????????-?o???TNS3???SEPT7????????????-?????????????(>10?1')???????o?????????????????????3???

 

???????????????o???????????????|?????????'?2????'?????????????????????????(?|??????????????10?1'??)?????????????????????o?????????????????????????????'???????????????????????????????????????1???????????????????o????????????????????????|???????1????????????'?????????????-??????????????????3????????????'??????|??????????????????????????-???????????

???????????|????4??a??o|????????????????????????????????????????????????

 


???1 ???????????????????

(1) ???????????o?????????????3????????(Two-stage GWAS survival analyses)???

?????????o??????????????(ILCCO)?????????????11299????????????????????????o???(NSCLC)??????????'?o??????????????GWAS???????????????????????????????

?????????????566?oo???????o??o????????o????????(HLCS)???a???????????733?oo???????o??o?MD?????????o????????(MDACC)???????????|?o????????(Liverpool)??????????????o?????o????????(CAPUA)?????????'??????????o????12????????(CARET)???????|???o???????????

??????????Cox???????????????????SNP????????????o??????3??????????????????a?????-???????????oo??a???????????????3?????

??????????????????'?????o????a??????????????NSCLC???????????????3???SNP???????o? 7p12.3??o???TNS3??o?????????rs34211819 (HR=0.73???P=3.90??10-9) ??????????????????'????????3?????????o?7p14.2??o???SEPT7??o?????????rs1143149 (HR=1.36???P=9.75??10-9)??????????????????'???????3???

 

???2 rs34211819???rs1143149???NSCLC???????3???????????

(2) ??o???-???????o?o????????????(Interaction analysis with smoking cessation)

???????????????????'??o?????????'???????????????????o???rs34211819???rs1143149????????????o???????????????????'????-???????????'??(rs34211819: ???'??P=0.042???rs1143149??????'??P=0.034)???Cox???????????????????o??a????aSNP??????????????????????????o?o??????????????????????????????1??????SNP??1?o??????????????????o????HR??????????o???????????1?????????????????????'????????????rs34211819????????????o???????????o(?o?o??????P=8.0??10-4)???????1????rs1143149???????????o???????????o(?o?o??????P =0.003)???

 

???3??o???-????????????o?o?????????

(3) ??????-|??????(multi-omics analyses)???

??????-??????o?o?TCGA???CPTAC???HLCS?-???????o???????TNS3???SEPT7????a??o?????????o?????????????????o?SNP???QTL?????3?3?????????o?????????DNA??2??o???????????'???o|????o?????????????3???????

??????????????TNS3???SEPT7????o?????????????o?????????????????3????????????????????????o|??????????????-???????????o??-???????????????o?????o?????????????a??2??o???CpG?????1???????-???????o|??????????3???

 

???4 TNS3???SEPT7??????-|?o?????????????????

(4) GWAS??????????????????(GWAS similarity comparison)???

??????????????????????-???????????????????????????-????????????NSCLC????o?????oo?????????????????3SNP?????????-?????????????SNP?????o???????????????????????1(eQTL???????????o?-????????'?13??????????????????????

??????????o???????????????????????????????1??'???????????????????o???-???????????????-????????????????????????o|????????????????????????????????????'??????o??????????????????????????????o?2????????????????????o?????????

??????????????????o??????????????NSCLC??????????1?????o??????????????????????????3??????????|?B?????????????????Th1/Th2?????????????????

 

?????????|???????????o????????????NSCLC???????????????3????a????????-??????????1???-?o?o????????????????????1??????????o??????????????????o???|??o??'????

????o????????-|????????????-|??????????????-|?3??2????1??????????-????????????????o?o????????????????????????????3???????????????3???????????????????????-|????????????-|??David C. Christiani????????o?o????????????????????????????????????????'????????-|??Christopher I. Amos???????????????????????????????????????-???Geoffrey Liu????????????????????|????-|Rayjean J. Hung?????????????????????|??-|John K. Field????????????????|??????????????????????????-???Chu Chen?????????????-????????'??????-|Adonina Tardon??????????????????????1??-|Yi Li?????????????o????????-|?2??'a????????????????????????????????????????????????????????

 

???????????:https://www.nature.com/articles/s41698-021-00182-3.pdf


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