球王会


中國科學院院士,國家心血管病中心原副主任、中國醫學科學院阜外醫院原副院長。南方科技大學代理副校長、醫學院講席教授,先后畢業于南京醫科大學和中國醫學科學院北京協和醫學院。分別于1983年、1986年、2007年獲得南京醫科大學醫學學士學位、中國協和醫科大學醫學碩士學位、北京協和醫學院理學博士學位。其間,1990.09--1992.10在美國明尼蘇達大學流行病學系和內科學系擔任訪問學者,1997年在加拿大多倫多大學擔任訪問教授,1999.02--2000.02在英國南安普敦大學人類遺傳系擔任訪問教授。現為中華預防醫學會副會長、世界衛生組織心血管和慢性病防治專家,國際心血管流行病學與預防學會常務理事, 中華預防醫學會心臟病預防與控制委員會全國主任委員;國家“健康中國行動”專家委員;北京協和醫學院教授、國家心血管病中心專家委員會副主任;中國醫學科學院學術咨詢委員會醫學學部執行委員會委員、中國醫學科學院學術咨詢委員會藥學-衛生健康與環境-生物醫學工程與信息學部副主任。國際雜志 American Journal of 等編委,Chronic Disease and Translational Medicine、《中華預防醫學雜志》、《中華流行病學雜志》、《中國循環雜志》等副主編。

預防心臟病學與流行病學家。長期從事心血管等慢性病的流行病學、人群防治和遺傳病因研究。揭示我國心血管病流行趨勢,解析環境、生活方式和遺傳因素在心血管病等慢性病發生發展中的作用,創建我國心腦血管病風險預測模型,牽頭制訂了《中國心血管病風險評估和管理指南》、《中國健康生活方式預防心血管代謝性疾病指南》,提出心血管疾病防治策略和措施。構建高脂血癥和冠心病遺傳特征譜,創建了冠心病基因組風險評估模型,推進了冠心病精準醫學研究,促進基礎研究向人群防治的轉化應用。先后承擔國家863計劃“高血壓全基因組關聯分析和藥物基因組學研究”和“高血壓分子分型和個體化診療技術”課題、973計劃“中國人動脈粥樣硬化遺傳分子基礎研究”、國家自然科學基金重點項目“冠心病全基因組關聯研究”、“中國高血壓調查隨訪及主要死亡影響因素研究”和“中國動脈粥樣硬化性心血管病預測China-PAR”兩個大型前瞻性隊列研究、“十三五”國家重點研發計劃我國大氣污染的慢性健康風險研究”,以及多項重要國際合作項目。獲得國家16項發明專利授權、牽頭的“中國心血管疾病發展趨勢和防治策略研究”和“中國人群高血壓和冠心病遺傳資源的收集和利用研究”獲得兩項國家科技進步二等獎。在心血管病因學和防治研究領域取得了重要的系統性創新成果,發表 SCI 論文300 余篇,含New Engl J MedLancetJAMABMJNat Genet等雜志;主編《預防心臟病學》,其研究成果被國內外防治指南和權威教科書及世界衛生組織專著等廣泛引用。

論文發表:2016-2020

1.Liang F, Liu F, Huang K, Yang X, Li J, Xiao Q, Chen J, Liu X, Cao J, Shen C, Yu L, Lu F, Wu X, Wu X, Li Y, Hu D, Huang J, Liu Y, Lu X and Gu D*. Long-Term Exposure to Fine Particulate Matter and Cardiovascular Disease in China. J Am Coll Cardiol. 2020;75:707-717.

2.Gu D*, et al. Chinese guideline on healthy lifestyle to prevent cardiometabolic diseases. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2020;54:256-277.

3.Xia X, Liu F, Yang X, Li J, Chen J, Liu X, Cao J, Shen C, Yu L, Zhao Y, Wu X, Zhao L, Li Y, Huang J, Lu X* and Gu D*. Associations of egg consumption with incident cardiovascular disease and all-cause mortality. Sci. China Life Sci. (2020). https://doi.org/10.1007/s11427-020-1656-8.

4.Wang X, Liu F, Li J, Yang X, Chen J, Cao J, Wu X, Lu X, Huang J, Li Y, Zhao L, Shen C, Hu D, Yu L, Liu X, Wu X, Wu S and Gu D*. Tea consumption and the risk of atherosclerotic cardiovascular disease and all-cause mortality: The China-PAR project. Eur J Prev Cardiol. 2020:2047487319894685.

5.Yang X, Liang F, Li J, Chen J, Liu F, Huang K, Cao J, Chen S, Xiao Q, Liu X, Shen C, Yu L, Lu F, Wu X, Wu X, Li Y, Zhao L, Hu D, Huang J, Lu X, Liu Y* and Gu D*. Associations of long-term exposure to ambient PM2.5 with mortality in Chinese adults: A pooled analysis of cohorts in the China-PAR project. Environment international. 2020;138:105589.

6.Huang K, Liang F, Yang X, Liu F, Li J, Xiao Q, Chen J, Liu X, Cao J, Shen C, Yu L, Lu F, Wu X, Zhao L, Wu X, Li Y, Hu D, Huang J, Liu Y, Lu X and Gu D*. Long term exposure to ambient fine particulate matter and incidence of stroke: prospective cohort study from the China-PAR project. BMJ. 2019;367:l6720.

7.Gu D*, et al. Joint Task Force for Guideline on the Assessment and Management of Cardiovascular Risk in China. Guideline on the assessment and management of cardiovascular risk in China. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2019;53:13-35.

8.Liu Q, Liu FC, Huang KY, Li JX, Yang XL, Wang XY, Chen JC, Liu XQ, Cao J, Shen C, Yu L, Lu FH, Wu XP, Zhao LC, Li Y, Hu DS, Lu XF, Huang JF and Gu D*. Beneficial effects of moderate to vigorous physical activity on cardiovascular disease among Chinese adults. J Geriatr Cardiol. 2020;17:85-95.

9.Gu X, Li Y, Chen S, Yang X, Liu F, Li Y, Li J, Cao J, Liu X, Chen J, Shen C, Yu L, Huang J, Lam TH, Fang X, He Y, Zhang X, Lu X, Wu S and Gu D*. Association of Lipids With Ischemic and Hemorrhagic Stroke: A Prospective Cohort Study Among 267 500 Chinese. Stroke. 2019;50:3376-84.

10.Xing X, Yang X, Liu F, Li J, Chen J, Liu X, Cao J, Shen C, Yu L, Lu F, Wu X, Zhao L, Li Y, Hu D, Lu X and Gu D. Predicting 10-Year and Lifetime Stroke Risk in Chinese Population. Stroke. 2019;50:2371-8.

11.Lu X, Yang H, Xia X, Lu X, Lin J, Liu F and Gu D. Interactive Mobile Health Intervention and Blood Pressure Management in Adults. Hypertension. 2019;74:697-704.

12.Wang L, Shen C, Wang Y, Zou T, Zhu H, Lu X, Li L, Yang B, Chen J, Chen S, Lu X and Gu D. Identification of circular RNA Hsa_circ_0001879 and Hsa_circ_0004104 as novel biomarkers for coronary artery disease. Atherosclerosis. 2019;286:88-96.

13.Huang K, Yang X, Liang F, Liu F, Li J, Xiao Q, Chen J, Liu X, Cao J, Shen C, Yu L, Lu F, Wu X, Zhao L, Wu X, Li Y, Hu D, Huang J, Liu Y, Lu X and Gu D. Long-Term Exposure to Fine Particulate Matter and Hypertension Incidence in China. Hypertension. 2019;73:1195-201.

14.Cai C, Zhu H, Ning X, Li L, Yang B, Chen S, Wang L, Lu X and Gu D. LncRNA ENST00000602558.1 regulates ABCG1 expression and cholesterol efflux from vascular smooth muscle cells through a p65-dependent pathway. Atherosclerosis. 2019;285:31-9.

15.Wang X, Yang X, Li J, Liu F, Chen J, Liu X, Cao J, Shen C, Yu L, Lu F, Wu X, Zhao L, Wu X, Li Y, Hu D, Huang J, Lu X and Gu D. Impact of healthy lifestyles on cancer risk in the Chinese population. Cancer. 2019;125:2099-106.

16.Liang F, Yang X, Liu F, Li J, Xiao Q, Chen J, Liu X, Cao J, Shen C, Yu L, Lu F, Wu X, Zhao L, Wu X, Li Y, Hu D, Huang J, Liu Y, Lu X and Gu D. Long-term exposure to ambient fine particulate matter and incidence of diabetes in China: A cohort study. Environ Int. 2019;126:568-75.

17.Han C, Hu Z, Liu F, Yang X, Kelly TN, Chen J, Huang J, Chen CS, He J, Chen S, Wu X, Gu D and Lu X. Genetic variants of cGMP-dependent protein kinase genes and salt sensitivity of blood pressure: the GenSalt study. J Hum Hypertens. 2019;33:62-8.

18.Xing X, Liu F, Yang X, Huang C, Zhang D, Chen S, Chen J, Li J, Liu Z, Lu F, Gu D and Huang J. Central Blood Pressure Responses to Dietary Sodium and Potassium Interventions. Am J Hypertens. 2018;31:582-9.

19.Li L, Wang L, Li H, Han X, Chen S, Yang B, Hu Z, Zhu H, Cai C, Chen J, Li X, Huang J and Gu D. Characterization of LncRNA expression profile and identification of novel LncRNA biomarkers to diagnose coronary artery disease. Atherosclerosis. 2018;275:359-67.

20.Huang K, Xiao Q, Meng X, Geng G, Wang Y, Lyapustin A, Gu D* and Liu Y*. Predicting monthly high-resolution PM2.5 concentrations with random forest model in the North China Plain. Environ Pollut. 2018;242:675-83.

21.Han C, Liu F, Yang X, Chen J, Li J, Cao J, Li Y, Shen C, Yu L, Liu Z, Wu X, Zhao L, Hu D, Lu X, Wu X and Gu D*. Ideal cardiovascular health and incidence of atherosclerotic cardiovascular disease among Chinese adults: the China-PAR project. Sci China Life Sci. 2018;61:504-14.

22.Gong X, Han X, Lu X, Chen J, Huang J, Kelly TN, Chen CS, He J, Gu D and Chen S. Association of Kir genes with blood pressure responses to dietary sodium intervention: the GenSalt study. Hypertens Res. 2018;41:1045-53.

23.Wang L, Li H, Yang B, Guo L, Han X, Li L, Li M, Huang J and Gu D. The Hypertension Risk Variant Rs820430 Functions as an Enhancer of SLC4A7. Am J Hypertens. 2017;30:202-8.

24.Lu X, Peloso GM, Liu DJ, Wu Y, Zhang H, Zhou W, Li J, Tang CS, Dorajoo R, Li H, Long J, Guo X, Xu M, Spracklen CN, Chen Y, Liu X, Zhang Y, Khor CC, Liu J, Sun L, Wang L, Gao YT, Hu Y, Yu K, Wang Y, Cheung CYY, Wang F, Huang J, Fan Q, Cai Q, Chen S, Shi J, Yang X, Zhao W, Sheu WH, Cherny SS, He M, Feranil AB, Adair LS, Gordon-Larsen P, Du S, Varma R, Chen YI, Shu XO, Lam KSL, Wong TY, Ganesh SK, Mo Z, Hveem K, Fritsche LG, Nielsen JB, Tse HF, Huo Y, Cheng CY, Chen YE, Zheng W, Tai ES, Gao W, Lin X, Huang W, Abecasis G, Consortium G, Kathiresan S, Mohlke KL, Wu T, Sham PC*, Gu D*and Willer CJ*. Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease. Nat Genet. 2017;49:1722-30.

25.Liu F, Yang X, Li J, Cao J, Chen J, Li Y, Liu X, Zhao L, Shen C, Yu L, Huang J and Gu D*. Association of fasting glucose levels with incident atherosclerotic cardiovascular disease: An 8-year follow-up study in a Chinese population. J Diabetes. 2017;9:14-23.

26.Li X, Yang Y, Wang L, Qiao S, Lu X, Wu Y, Xu B, Li H and Gu D*. Elevated plasma miRNA-122, -140-3p, -720, -2861, and -3149 during early period of acute coronary syndrome are derived from peripheral blood mononuclear cells. PLoS One. 2017;12:e0184256.

27.Huang C, Moran AE, Coxson PG, Yang X, Liu F, Cao J, Chen K, Wang M, He J, Goldman L, Zhao D, Kinney PL and Gu D*. Potential Cardiovascular and Total Mortality Benefits of Air Pollution Control in Urban China. Circulation. 2017;136:1575-84.

28.Han X, Hu Z, Chen J, Huang J, Huang C, Liu F, Gu C, Yang X, Hixson JE, Lu X, Wang L, Liu DP, He J, Chen S and Gu D*. Associations Between Genetic Variants of NADPH Oxidase-Related Genes and Blood Pressure Responses to Dietary Sodium Intervention: The GenSalt Study. Am J Hypertens. 2017;30:427-34.

29.Zhang D, Cao J, Dong Z, Li J, Li G, Ma A, Yang X, Liu F, Chen J, Huang J and Gu D*. Prevalence of active and passive tobacco smoking among Beijing residents in 2011. Chronic Dis Transl Med. 2016;2:120-8.

30.Yang X, Chen J, Li J, Cao J, Lu X, Liu F, Hu D, Liu X, Shen C, Yu L, Lu F, Wu X, Zhao L, Huang J, Li Y, Wu X and Gu D*. Risk stratification of atherosclerotic cardiovascular disease in Chinese adults. Chronic Dis Transl Med. 2016;2:102-9.

31.Yang X, Li J, Hu D, Chen J, Li Y, Huang J, Liu X, Liu F, Cao J, Shen C, Yu L, Lu F, Wu X, Zhao L, Wu X and Gu D*. Predicting the 10-Year Risks of Atherosclerotic Cardiovascular Disease in Chinese Population: The China-PAR Project (Prediction for ASCVD Risk in China). Circulation. 2016;134:1430-40.

32.Xue H, Wang C, Li Y, Chen J, Yu L, Liu X, Li J, Cao J, Deng Y, Guo D, Yang X, Huang J and Gu D*. Incidence of type 2 diabetes and number of events attributable to abdominal obesity in China: A cohort study. J Diabetes. 2016;8:190-8.

33.Lu X, Li J, Li H, Chen Y, Wang L, He M, Wang Y, Sun L, Hu Y, Huang J, Wang F, Liu X, Chen S, Yu K, Yang X, Mo Z, Lin X, Wu T and Gu D*. Coding-sequence variants are associated with blood lipid levels in 14,473 Chinese. Hum Mol Genet. 2016;25:4107-16.

34.Huang K, Liu F, Han X, Huang C, Huang J, Gu D and Yang X. Association of BMI with total mortality and recurrent stroke among stroke patients: A meta-analysis of cohort studies. Atherosclerosis. 2016;253:94-101.

35.Hu Z, Liu F, Li M, He J, Huang J, Rao DC, Hixson JE, Gu C, Kelly TN, Chen S, Gu D and Yang X. Associations of Variants in the CACNA1A and CACNA1C Genes With Longitudinal Blood Pressure Changes and Hypertension Incidence: The GenSalt Study. Am J Hypertens. 2016;29:1301-6.

36.Guo L, Wang L, Li H, Yang X, Yang B, Li M, Huang J and Gu D. Down regulation of GALNT3 contributes to endothelial cell injury via activation of p38 MAPK signaling pathway. Atherosclerosis. 2016;245:94-100.

37.Guo L, Liu F, Chen S, Yang X, Huang J, He J, Jaquish CE, Zhao Q, Gu CC, Hixson JE and Gu D*. Common variants in the Na(+)-coupled bicarbonate transporter genes and salt sensitivity of blood pressure: the GenSalt study. J Hum Hypertens. 2016;30:543-8.

38.Feng B, Huang C, Cao J, Dong Z, Liu F, Ji L, Yang J, Li G, Li J, Yang X, Xie J, Fang K, Huang J and Gu D*. Diabetes awareness, treatment, control rates and associated risk factors among Beijing residents in 2011: A cross-sectional survey. Chronic Dis Transl Med. 2016;2:147-58.

39.Chen S, Huang J, Zhao Q, Chen J, Jaquish CE, He J, Lu X, Yang X, Gu CC, Hixson JE, Liu F, Rice TK, Cao J, Chen J and Gu D. Associations Between Genetic Variants of the Natriuretic Peptide System and Blood Pressure Response to Dietary Sodium Intervention: The GenSalt Study. Am J Hypertens. 2016;29:397-404.

40.Brook RD, Sun Z, Brook JR, Zhao X, Ruan Y, Yan J, Mukherjee B, Rao X, Duan F, Sun L, Liang R, Lian H, Zhang S, Fang Q, Gu D, Sun Q, Fan Z and Rajagopalan S. Extreme Air Pollution Conditions Adversely Affect Blood Pressure and Insulin Resistance: The Air Pollution and Cardiometabolic Disease Study. Hypertension. 2016;67:77-85.

榮譽獎項

2004年衛生部有突出貢獻中青年專家榮譽稱號;

2004年新世紀百千萬人才工程國家級專家榮譽稱號;

2005年國務院政府特殊津貼;

2007年中華預防醫學會科學技術獎一等獎;        

2008年中華醫學科技獎一等獎;

2008年國家科學技術進步獎二等獎;

2009年國家科學技術進步獎二等獎;

2016年全國優秀科技工作者榮譽稱號。



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